MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery.
نویسندگان
چکیده
Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.
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عنوان ژورنال:
- Chemical communications
دوره 51 3 شماره
صفحات -
تاریخ انتشار 2015